Zuwan Lin, PhD
Postdoctoral Researcher
Harvard University
Postdoctoral Researcher
Harvard University
Currently I am a postdoctoral researcher in the School of Engineering and Applied Sciences at Harvard University, working with Prof. Na Li. Prior to this, I was co-advised by Prof. Jia Liu at Harvard University and Prof. Xiao Wang at Broad Institute of MIT and Harvard, and earned my Ph.D. in physical chemistry from Harvard University in 2024. I have also worked closely with Prof. Richard T. Lee, Prof. Juan Alvarez, and Prof. Jie Ding. I earned my B.S. in chemical biology from Tsinghua University in 2018.
My research decodes how cells orchestrate functional tissues by integrating three technological frontiers: bioelectronics, spatial transcriptomics, and agentic AI. First, I pioneered cyborg engineering which embeds tissue-like stretchable nanoelectronics into developing cardiac, neural, and pancreatic organoids or into living animals to capture continuous single-cell electrical activity over months. Second, I developed in situ electro-seq, which pairs millisecond-scale electrical recordings with 3D spatial transcriptomics from the same cells, revealing how molecular programs drive cellular function. Third, I create autonomous AI agents powered by multimodal large language models: SpikeAgent automates neural spike sorting with interpretable decision-making, STAgent conducts spatial transcriptomic analysis while integrating scientific literature, and BehaveAgent performs universal behavior analysis from raw video. These agents transform weeks of expert analysis into minutes of automated discovery. By integrating chronic bioelectronic sensing, multimodal molecular profiling, and intelligent automation, my research aims to revolutionize how we study development, disease, and regeneration across biological scales.
* Denotes equal contribution, # Denotes corresponding author
